Generation of Highly Purified Human Cardiomyocytes from Peripheral Blood Mononuclear Cell-Derived Induced Pluripotent Stem Cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-319725
DOI to cite this document:: 10.5283/epub.31972

Zimmermann, Martina E. ; Fuerstenau-Sharp, Maya ; Stark, Klaus ; Jentsch, Nico ; Klingenstein, Melanie ; Drzymalski, Marzena ; Wagner, Stefan ; Maier, Lars S. ; Baessler, Andrea ; Fischer, Marcus ; Hengstenberg, Christian ; Hehr, Ute

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Date of publication of this fulltext: 18 Jun 2015 15:43

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Abstract

Induced pluripotent stem (iPS) cells have an enormous potential for physiological studies. A novel protocol was developed combining the derivation of iPS from peripheral blood with an optimized directed differentiation to cardiomyocytes and a subsequent metabolic selection. The human iPS cells were retrovirally dedifferentiated from activated T cells. The subsequent optimized directed ...