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An assessment of catalytic residue 3D ensembles for the prediction of enzyme function

Merkl, Rainer, Žváček, Clemens, Heizinger, Leonhard and Friedrichs, Gerald (2015) An assessment of catalytic residue 3D ensembles for the prediction of enzyme function. BMC Bioinformatics 16 (359), pp. 1-8.

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Date of publication of this fulltext: 14 Dec 2015 09:15

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Other URL: http://www.biomedcentral.com/1471-2105/16/359


Abstract

Background The central element of each enzyme is the catalytic site, which commonly catalyzes a single biochemical reaction with high specificity. It was unclear to us how often sites that catalyze the same or highly similar reactions evolved on different, i. e. non-homologous protein folds and how similar their 3D poses are. Both similarities are key criteria for assessing the usability of pose ...

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Item type:Article
Date:4 November 2015
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s12859-015-0807-6DOI
Keywords:Catalytic site; Pose comparison; Enzyme function; Enzyme classification
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33051
Owner only: item control page

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