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Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

URN to cite this document:
urn:nbn:de:bvb:355-epub-333767
DOI to cite this document:
10.5283/epub.33376
Jantsch, Jonathan ; Schatz, Valentin ; Dettmer, Katja ; Dick, Christopher ; Ehrenschwender, Martin ; Hellerbrand, Claus ; Oefner, Peter J.
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Date of publication of this fulltext: 24 Feb 2016 13:09



Abstract

Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1α and nuclear factor (NF)-κB, which play a crucial role in adaptive responses to these challenges. In dendritic cells (DC), lipopolysaccharide (LPS)-induced HIF1α accumulation requires NF-κB signaling and promotes inflammatory DC function. The mechanisms that drive LPS-induced HIF1α ...

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