Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-333767

Jantsch, Johnathan, Schatz, Valentin, Dettmer, Katja, Dick, Chritstopher, Ehrenschwender, Martin, Hellerbrand, Claus und Oefner, Peter J. (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen. Cell Reports 2015 (13), S. 2048-2055.

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Andere URL zum Volltext: http://www.cell.com/cell-reports/abstract/S2211-1247%2815%2901292-9

Zusammenfassung

Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1α and nuclear factor (NF)-κB, which play a crucial role in adaptive responses to these challenges. In dendritic cells (DC), lipopolysaccharide (LPS)-induced HIF1α accumulation requires NF-κB signaling and promotes inflammatory DC function. The mechanisms that drive LPS-induced HIF1α ...