Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

URN to cite this document:: urn:nbn:de:bvb:355-epub-333767
DOI to cite this document:: 10.5283/epub.33376

Jantsch, Jonathan ; Schatz, Valentin ; Dettmer, Katja

; Dick, Christopher ; Ehrenschwender, Martin

; Hellerbrand, Claus ; Oefner, Peter J.

Preview

PDF
(1MB)

Date of publication of this fulltext: 24 Feb 2016 13:09

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1 alpha and nuclear factor (NF)-kappa B, which play a crucial role in adaptive responses to these challenges. In dendritic cells (DC), lipopolysaccharide (LPS)-induced HIF1 alpha accumulation requires NF-kappa B signaling and promotes inflammatory DC function. The mechanisms that drive ...