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Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

Jantsch, Johnathan, Schatz, Valentin, Dettmer, Katja, Dick, Chritstopher, Ehrenschwender, Martin, Hellerbrand, Claus and Oefner, Peter J. (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen. Cell Reports 2015 (13), pp. 2048-2055.

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Date of publication of this fulltext: 24 Feb 2016 13:09

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Other URL: http://www.cell.com/cell-reports/abstract/S2211-1247%2815%2901292-9


Abstract

Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1α and nuclear factor (NF)-κB, which play a crucial role in adaptive responses to these challenges. In dendritic cells (DC), lipopolysaccharide (LPS)-induced HIF1α accumulation requires NF-κB signaling and promotes inflammatory DC function. The mechanisms that drive LPS-induced HIF1α ...

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Item type:Article
Date:15 December 2015
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1016/j.celrep.2015.11.005DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:33376
Owner only: item control page

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