Jantsch, Johnathan, Schatz, Valentin, Dettmer, Katja, Dick, Chritstopher, Ehrenschwender, Martin, Hellerbrand, Claus and Oefner, Peter J. (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen. Cell Reports 2015 (13), pp. 2048-2055.
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Other URL: http://www.cell.com/cell-reports/abstract/S2211-1247%2815%2901292-9
Abstract
Both hypoxic and inflammatory conditions activate transcription factors such as hypoxia-inducible factor (HIF)-1α and nuclear factor (NF)-κB, which play a crucial role in adaptive responses to these challenges. In dendritic cells (DC), lipopolysaccharide (LPS)-induced HIF1α accumulation requires NF-κB signaling and promotes inflammatory DC function. The mechanisms that drive LPS-induced HIF1α ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 15 December 2015 | ||||
| Institutions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 33376 |
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