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Evolutionary Pareto-optimization of stably folding peptides

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Gronwald, Wolfram ; Hohm, T. ; Hoffmann, D.
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Date of publication of this fulltext: 11 Apr 2016 13:08


Background As a rule, peptides are more flexible and unstructured than proteins with their substantial stabilizing hydrophobic cores. Nevertheless, a few stably folding peptides have been discovered. This raises the question whether there may be more such peptides that are unknown as yet. These molecules could be helpful in basic research and medicine. Results As a method to explore the space of ...


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