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Structure of the initaton-competent RNA polymerase I and its implication for transcription

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Tschochner, Herbert ; Pilsl, Michael ; Crusifix, Corinne ; Papai, Garbor ; Krupp, Ferdinand ; Steinbauer, Robert ; Griesenbeck, Joachim ; Milkereit, Philipp ; Schultz, Patrick
Date of publication of this fulltext: 29 Jul 2016 06:29


Eukaryotic RNA polymerase I (Pol I) is specialized in rRNA gene transcription synthesizing up to 60% of cellular RNA. High level rRNA production relies on efficient binding of initiation factors to the rRNA gene promoter and recruitment of Pol I complexes containing initiation factor Rrn3. Here, we determine the cryo-EM structure of the Pol I-Rrn3 complex at 7.5 angstrom resolution, and compare ...


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