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Structure of the initaton-competent RNA polymerase I and its implication for transcription

Tschochner, Herbert, Pilsl, Michael, Crusifix, Corinne, Papai, Garbor, Krupp, Ferdinand, Steinbauer, Robert, Griesenbeck, Joachim, Milkereit, Philipp and Schultz, Patrick (2016) Structure of the initaton-competent RNA polymerase I and its implication for transcription. Nature Communications 7 (12126), pp. 1-12.

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Date of publication of this fulltext: 29 Jul 2016 06:29

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Other URL: http://www.nature.com/ncomms/2016/160715/ncomms12126/full/ncomms12126.html


Abstract

Eukaryotic RNA polymerase I (Pol I) is specialized in rRNA gene transcription synthesizing up to 60% of cellular RNA. High level rRNA production relies on efficient binding of initiation factors to the rRNA gene promoter and recruitment of Pol I complexes containing initiation factor Rrn3. Here, we determine the cryo-EM structure of the Pol I-Rrn3 complex at 7.5 Å resolution, and compare it with ...

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Item type:Article
Date:15 July 2016
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Herbert Tschochner
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/ncomms12126DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:34042
Owner only: item control page

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