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Non-transcriptional pathway features reconstructed from secondary effects of RNA interference

Markowetz, F. ; Bloch, J. ; Spang, Rainer



Abstract

Motivation: Cellular signaling pathways, which are not modulated on a transcriptional level, cannot be directly deduced from expression profiling experiments. The situation changes, when external interventions such as RNA interference or gene knock-outs come into play. Even if the expression of the signaling genes is not changed, secondary effects in downstream genes shed light on the pathway, ...

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