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CD8+ T cell epitope-enriched HIV-1-Gag antigens with preserved structure and function

Meier, Johannes Peter (2017) CD8+ T cell epitope-enriched HIV-1-Gag antigens with preserved structure and function. PhD, Universität Regensburg.

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Date of publication of this fulltext: 27 Mar 2017 07:59

Abstract (English)

Control of disease progression in certain HIV-1 infected individuals is often associated with CD8+ T cell responses directed towards Gag-derived epitopes presented on HLA class I molecules. This indicates that such responses play a crucial role in combating virus replication. However, both the large variability of HIV-1 and the diversity of HLA alleles impose a challenge on the elicitation of ...

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Translation of the abstract (German)

Bei bestimmten HIV-1 infizierten Personen, welche den Krankheitsverlauf weitgehend kontrollieren können, ist eine solche Kontrolle häufig verbunden mit CD8+ T-Zell Antworten gegen Gag-spezifische Epitope, welche auf HLA Klasse I Molekülen präsentiert werden. Dies deutet darauf hin, dass solche Antworten bei der Inhibition der Virusreplikation eine entscheidende Rolle einnehmen. Bei der ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:27 March 2017
Referee:Prof. Dr. Ralf Wagner
Date of exam:7 February 2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Keywords:HIV-1, Gag, T cell vaccine, CD8 T cell, Virus-like particles, Vaccine design, epitopes
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35412
Owner only: item control page

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