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Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3)

URN to cite this document:
urn:nbn:de:bvb:355-epub-354659
DOI to cite this document:
10.5283/epub.35465
Stöhr, H. ; Roomp, K. ; Felbor, U. ; Weber, Bernhard H. F.
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 11 Apr 2017 11:30


Abstract

The tissue inhibitors of metalloproteinases (TIMPs) play a crucial role in the physiological turnover of the extracellular matrix (ECM) by tightly regulating matrix metalloproteinase (MMP) activities. Disturbances in the TIMP/MMP system have been implicated in many disease processes where loss of ECM integrity is a principal feature. More recently, we have shown that mutations in TIMP3 cause the ...

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