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Impact of an anti-metabolic therapy on leukemic and non-malignant T cells

Fante, Matthias (2018) Impact of an anti-metabolic therapy on leukemic and non-malignant T cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 01 Mar 2018 05:55

Abstract (English)

Human T-ALL cells as solid tumor cells exhibit a metabolic phenotype characterized by an upregulated glucose uptake and lactate secretion despite sufficient oxygen supply (= Warburg effect). Stimulated and re-stimulated human T lymphocytes show a similar metabolic shift towards aerobic glycolysis. However, glucose metabolism is not elevated during the initial phase of stimulation when cell growth ...

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Translation of the abstract (German)

Humane T-ALL Zellen und solide Tumorzellen weisen einen metabolischen Phänotyp auf, der gekennzeichnet ist durch gesteigerte Glukoseaufnahme und Laktatsekretion trotz ausreichender Sauerstoffzufuhr (= Warburg-Effekt). Stimulierte und re-stimulierte T-Lymphozyten ähneln in ihrem Metabolismus den Tumorzellen. In der Anfangsphase der (Re-)Stimulation, in der Zellwachstum und Zytokinproduktion ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:1 March 2018
Referee:Prof. Dr. Marina Kreutz
Date of exam:21 September 2017
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Keywords:Warburg effect, aerobic glycolysis, tumor metabolism, T cell metabolism, immune escape, lactic acid, anti-glycolytic therapy, immunotherapy, diclofenac, 2-deoxyglucose
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36253
Owner only: item control page

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