Go to content
UR Home

Impact of an anti-metabolic therapy on leukemic and non-malignant T cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-362539
DOI to cite this document:
10.5283/epub.36253
Fante, Matthias
Date of publication of this fulltext: 01 Mar 2018 05:55


Abstract (English)

Human T-ALL cells as solid tumor cells exhibit a metabolic phenotype characterized by an upregulated glucose uptake and lactate secretion despite sufficient oxygen supply (= Warburg effect). Stimulated and re-stimulated human T lymphocytes show a similar metabolic shift towards aerobic glycolysis. However, glucose metabolism is not elevated during the initial phase of stimulation when cell growth ...

plus

Translation of the abstract (German)

Humane T-ALL Zellen und solide Tumorzellen weisen einen metabolischen Phänotyp auf, der gekennzeichnet ist durch gesteigerte Glukoseaufnahme und Laktatsekretion trotz ausreichender Sauerstoffzufuhr (= Warburg-Effekt). Stimulierte und re-stimulierte T-Lymphozyten ähneln in ihrem Metabolismus den Tumorzellen. In der Anfangsphase der (Re-)Stimulation, in der Zellwachstum und Zytokinproduktion ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons