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Impact of an anti-metabolic therapy on leukemic and non-malignant T cells

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Fante, Matthias
Date of publication of this fulltext: 01 Mar 2018 05:55

Abstract (English)

Human T-ALL cells as solid tumor cells exhibit a metabolic phenotype characterized by an upregulated glucose uptake and lactate secretion despite sufficient oxygen supply (= Warburg effect). Stimulated and re-stimulated human T lymphocytes show a similar metabolic shift towards aerobic glycolysis. However, glucose metabolism is not elevated during the initial phase of stimulation when cell growth ...


Translation of the abstract (German)

Humane T-ALL Zellen und solide Tumorzellen weisen einen metabolischen Phänotyp auf, der gekennzeichnet ist durch gesteigerte Glukoseaufnahme und Laktatsekretion trotz ausreichender Sauerstoffzufuhr (= Warburg-Effekt). Stimulierte und re-stimulierte T-Lymphozyten ähneln in ihrem Metabolismus den Tumorzellen. In der Anfangsphase der (Re-)Stimulation, in der Zellwachstum und Zytokinproduktion ...


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