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1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

URN to cite this document:
urn:nbn:de:bvb:355-epub-365822
DOI to cite this document:
10.5283/epub.36582
Gorski, Mathias ; van der Most, Peter J. ; Teumer, Alexander ; Chu, Audrey Y. ; Li, Man ; Mijatovic, Vladan ; Nolte, Ilja M. ; Cocca, Massimiliano ; Taliun, Daniel ; Gomez, Felicia ; Li, Yong ; Tayo, Bamidele ; Tin, Adrienne ; Feitosa, Mary F. ; Aspelund, Thor ; Attia, John ; Biffar, Reiner ; Bochud, Murielle ; Boerwinkle, Eric ; Borecki, Ingrid ; Bottinger, Erwin P. ; Chen, Ming-Huei ; Chouraki, Vincent ; Ciullo, Marina ; Coresh, Josef ; Cornelis, Marilyn C. ; Curhan, Gary C. ; d’Adamo, Adamo Pio ; Dehghan, Abbas ; Dengler, Laura ; Ding, Jingzhong ; Eiriksdottir, Gudny ; Endlich, Karlhans ; Enroth, Stefan ; Esko, Tõnu ; Franco, Oscar H. ; Gasparini, Paolo ; Gieger, Christian ; Girotto, Giorgia ; Gottesman, Omri ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Hancock, Stephen J. ; Harris, Tamara B. ; Helmer, Catherine ; Höllerer, Simon ; Hofer, Edith ; Hofman, Albert ; Holliday, Elizabeth G. ; Homuth, Georg ; Hu, Frank B. ; Huth, Cornelia ; Hutri-Kähönen, Nina ; Hwang, Shih-Jen ; Imboden, Medea ; Johansson, Åsa ; Kähönen, Mika ; König, Wolfgang ; Kramer, Holly ; Krämer, Bernhard K. ; Kumar, Ashish ; Kutalik, Zoltan ; Lambert, Jean-Charles ; Launer, Lenore J. ; Lehtimäki, Terho ; de Borst, Martin ; Navis, Gerjan ; Swertz, Morris ; Liu, Yongmei ; Lohman, Kurt ; Loos, Ruth J. F. ; Lu, Yingchang ; Lyytikäinen, Leo-Pekka ; McEvoy, Mark A. ; Meisinger, Christa ; Meitinger, Thomas ; Metspalu, Andres ; Metzger, Marie ; Mihailov, Evelin ; Mitchell, Paul ; Nauck, Matthias ; Oldehinkel, Albertine J. ; Olden, Matthias ; Penninx, Brenda W. J. H. ; Pistis, Giorgio ; Pramstaller, Peter P. ; Probst-Hensch, Nicole ; Raitakari, Olli T. ; Rettig, Rainer ; Ridker, Paul M. ; Rivadeneira, Fernando ; Robino, Antonietta ; Rosas, Sylvia E. ; Ruderfer, Douglas ; Ruggiero, Daniela ; Saba, Yasaman ; Sala, Cinzia ; Schmidt, Helena ; Schmidt, Reinhold ; Scott, Rodney J. ; Sedaghat, Sanaz ; Smith, Albert V. ; Sorice, Rossella ; Stengel, Benedicte ; Stracke, Sylvia ; Strauch, Konstantin ; Toniolo, Daniela ; Uitterlinden, Andre G. ; Ulivi, Sheila ; Viikari, Jorma S. ; Völker, Uwe ; Vollenweider, Peter ; Völzke, Henry ; Vuckovic, Dragana ; Waldenberger, Melanie ; Jin Wang, Jie ; Yang, Qiong ; Chasman, Daniel I. ; Tromp, Gerard ; Snieder, Harold ; Heid, Iris M. ; Fox, Caroline S. ; Köttgen, Anna ; Pattaro, Cristian ; Böger, Carsten A. ; Fuchsberger, Christian
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Date of publication of this fulltext: 25 Jan 2018 12:05



Abstract

HapMap imputed genome-wide association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete ...

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