Go to content
UR Home

Effects of genetic variants in the TSPO gene on protein structure and stability

Milenkovic, Vladimir M., Bader, Stefanie, Sudria-Lopez, Daniel, Siebert, Ramona, Brandl, Caroline, Nothdurfter, Caroline, Weber, Bernhard H. F., Rupprecht, Rainer and Wetzel, Christian H. (2018) Effects of genetic variants in the TSPO gene on protein structure and stability. PLOS ONE 13 (4), e0195627.

[img]
Preview
License: Creative Commons Attribution 4.0
PDF
Download (6MB)
Date of publication of this fulltext: 15 May 2018 10:52

at publisher (via DOI)

Other URL: http://doi.org/10.1371/journal.pone.0195627


Abstract

The 18 kDa translocator protein (TSPO) is an evolutionary conserved cholesterol binding protein localized in the outer mitochondrial membrane. Expression of TSPO is upregulated in activated microglia in various neuroinflammatory, neurodegenerative, and neoplastic disorders. Therefore, TSPO radioligands are used as biomarkers in positron emission tomography (PET) studies. In particular, a common ...

plus


Export bibliographical data



Item type:Article
Date:11 April 2018
Institutions:Medicine > Lehrstuhl für Neurologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0195627DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37328
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons