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A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)—The Case of Herbal Medicinal Products Containing St. John’s Wort Extracts (SJW)

Habs, Michael, Binder, Karin , Krauss, Stefan, Müller, Karolina, Ernst, Brigitte, Valentini, Luzia and Koller, Michael (2018) A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)—The Case of Herbal Medicinal Products Containing St. John’s Wort Extracts (SJW). Nutrients 10 (7), p. 804.

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Date of publication of this fulltext: 25 Jun 2018 13:28

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Other URL: http://doi.org/10.3390/nu10070804, http://www.mdpi.com/2072-6643/10/7/804


Abstract

Objectives: Pyrrolizidine alkaloids (PA) exist ubiquitously in our environment. More than 6000 plants, about 3% of the world’s flowering plants, are known to synthesize PA. As a consequence, many herbal ingredients, including St. John’s wort (SJW), are contaminated with PA that can possess acute and subchronic toxic effects as well as mutagenic and genotoxic properties. Therefore, the possible ...

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Item type:Article
Date:22 June 2018
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3390/nu10070804DOI
Keywords:pyrrolizidine alkaloids (PA); risk-benefit analysis; St. John’s wort extract (SJW)
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37423
Owner only: item control page

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