A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)—The Case of Herbal Medicinal Products Containing St. John’s Wort Extracts (SJW)

URN to cite this document:: urn:nbn:de:bvb:355-epub-374238
DOI to cite this document:: 10.5283/epub.37423

Habs, Michael ; Binder, Karin

; Krauss, Stefan

; Müller, Karolina ; Ernst, Brigitte ; Valentini, Luzia ; Koller, Michael

Preview

License: Creative Commons Attribution 4.0
PDF
(1MB)

PDF
(1MB) - Repository staff only

Date of publication of this fulltext: 25 Jun 2018 13:28

Alternative links to fulltext:DOI Webofscience Publisher Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Objectives: Pyrrolizidine alkaloids (PA) exist ubiquitously in our environment. More than 6000 plants, about 3% of the world’s flowering plants, are known to synthesize PA. As a consequence, many herbal ingredients, including St. John’s wort (SJW), are contaminated with PA that can possess acute and subchronic toxic effects as well as mutagenic and genotoxic properties. Therefore, the possible ...