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A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

Winkler, Thomas W, Günther, Felix, Höllerer, Simon, Zimmermann, Martina, Loos, Ruth JF, Kutalik, Zoltán and Heid, Iris M (2018) A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications. Nature Communications 9 (1946), pp. 1-13.

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Date of publication of this fulltext: 26 Jun 2018 08:53

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Other URL: http://doi.org/10.1038/s41467-018-04124-9, https://www.nature.com/articles/s41467-018-04124-9


Abstract

The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here, we adopt a joint view of adiposity traits in ~322,154 subjects (GIANT consortium). We classify 159 signals associated with body mass index (BMI), waist-to-hip ratio (WHR), or WHR adjusted for BMI (WHRadjBMI) at P < 5 × 10−8, into four ...

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Item type:Article
Date:16 May 2018
Institutions:Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/s41467-018-04124-9DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37428
Owner only: item control page

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