A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

URN to cite this document:: urn:nbn:de:bvb:355-epub-374281
DOI to cite this document:: 10.5283/epub.37428

Winkler, Thomas W.

; Günther, Felix ; Höllerer, Simon ; Zimmermann, Martina

; Loos, Ruth J. F.

; Kutalik, Zoltán ; Heid, Iris M.

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Date of publication of this fulltext: 22 Apr 2021 13:59

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Abstract

The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here, we adopt a joint view of adiposity traits in similar to 322,154 subjects (GIANT consortium). We classify 159 signals associated with body mass index (BMI), waist-to-hip ratio (WHR), or WHR adjusted for BMI (WHRadjBMI) at P < 5 x 10(-8), ...