TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

URN to cite this document:: urn:nbn:de:bvb:355-epub-376824
DOI to cite this document:: 10.5283/epub.37682

Riquelme, Paloma

; Haarer, Jan ; Kammler, Anja ; Walter, Lisa

; Tomiuk, Stefan ; Ahrens, Norbert

; Wege, Anja K.

; Goecze, Ivan ; Zecher, Daniel ; Banas, Bernhard

; Spang, Rainer

; Fändrich, Fred ; Lutz, Manfred B. ; Sawitzki, Birgit ; Schlitt, Hans J.

; Ochando, Jordi

; Geissler, Edward K.

; Hutchinson, James A.

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 30 Aug 2018 14:10

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Abstract

Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4(+) T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4(+) T cells to IL-10-producing, TIGIT(+) FoxP3(+)-induced ...