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TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

Riquelme, Paloma , Haarer, Jan, Kammler, Anja, Walter, Lisa , Tomiuk, Stefan, Ahrens, Norbert , Wege, Anja K. , Goecze, Ivan, Zecher, Daniel, Banas, Bernhard , Spang, Rainer, Fändrich, Fred, Lutz, Manfred B., Sawitzki, Birgit, Schlitt, Hans J. , Ochando, Jordi , Geissler, Edward K. and Hutchinson, James A. (2018) TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity. Nature Communications 9 (2858), pp. 1-18.

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Date of publication of this fulltext: 30 Aug 2018 14:10

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Other URL: http://doi.org/10.1038/s41467-018-05167-8, https://www.nature.com/articles/s41467-018-05167-8


Abstract

Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4+ T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4+ T cells to IL-10-producing, TIGIT+ FoxP3+-induced ...

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Item type:Article
Date:20 July 2018
Institutions:Medicine > Lehrstuhl für Chirurgie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/s41467-018-05167-8DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37682
Owner only: item control page

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