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TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

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Riquelme, Paloma ; Haarer, Jan ; Kammler, Anja ; Walter, Lisa ; Tomiuk, Stefan ; Ahrens, Norbert ; Wege, Anja K. ; Goecze, Ivan ; Zecher, Daniel ; Banas, Bernhard ; Spang, Rainer ; Fändrich, Fred ; Lutz, Manfred B. ; Sawitzki, Birgit ; Schlitt, Hans J. ; Ochando, Jordi ; Geissler, Edward K. ; Hutchinson, James A.
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Date of publication of this fulltext: 30 Aug 2018 14:10


Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4(+) T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4(+) T cells to IL-10-producing, TIGIT(+) FoxP3(+)-induced ...


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