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Furo[2,3-b]furanones in Natural Products: Synthesis, Derivatization and Biological Evaluation of (+)-Paeonilide and Studies toward Dermatolactone

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Gnahn, Matthias
Date of publication of this fulltext: 07 Jan 2021 07:44

Abstract (English)

The furo[2,3-b]furanone moiety is present in more than 100 natural products. Two representatives of this class which are substituted in the C-4 position are the highly oxygenated monoterpenoid (+) paeonilide (49) and the sesquiterpene dermatolactone (199). In the present thesis, an enantioselective synthesis of (+)-paeonilide (49) and derivatives was developed and their biological activity ...


Translation of the abstract (German)

Die Furo[2,3-b]furanonstruktur kommt in mehr als 100 Naturstoffen vor. Zwei Vertreter dieser Klasse, welche in der C-4-Position substituiert sind, sind das sauerstoffreiche Monoterpen (+) Paeonilid (49) und das Sesquiterpen Dermatolacton (199). In der vorliegenden Arbeit wurde eine enantioselektive Synthese von (+)-Paeonilid (49) und verschiedenen Derivaten entwickelt und deren biologische ...


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