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Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition

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Bülow, Sigrid ; Zeller, Lisa ; Werner, Maren ; Toelge, Martina ; Holzinger, Jonas ; Entzian, Clemens ; Schubert, Thomas ; Waldow, Franziska ; Gisch, Nicolas ; Hammerschmidt, Sven ; Gessner, André
Date of publication of this fulltext: 29 Jan 2019 12:23


Adequate perception of immunologically important pathogen-associated molecular patterns like lipopolysaccharide and bacterial lipoproteins is essential for efficient innate and adaptive immune responses. In the context of Gram-negative infection, bactericidal/permeability-increasing protein (BPI) neutralizes endotoxic activity of lipopolysaccharides, and thus prohibits hyperactivation. So far, no ...


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