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Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe

Freisling, Heinz ; Arnold, Melina ; Soerjomataram, Isabelle ; O'Doherty, Mark George ; Ordóñez-Mena, José Manuel ; Bamia, Christina ; Kampman, Ellen ; Leitzmann, Michael ; Romieu, Isabelle ; Kee, Frank ; Tsilidis, Konstantinos ; Tjønneland, Anne ; Trichopoulou, Antonia ; Boffetta, Paolo ; Benetou, Vassiliki ; Bueno-de-Mesquita, Bas ; Huerta, José María ; Brenner, Hermann ; Wilsgaard, Tom ; Jenab, Mazda


Background: We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obesity, with total obesity-related and site-specific (colorectal and ...


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