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Selektive HDAC6-Inhibitoren: Synthese und biologische Testung

URN to cite this document:
urn:nbn:de:bvb:355-epub-400524
DOI to cite this document:
10.5283/epub.40052
Grünstein, Elisabeth
Date of publication of this fulltext: 10 Apr 2019 07:57


Abstract (German)

Epigenetische Therapieansätze als vielversprechende pharmakologische Intervention zur Behandlung einer Vielzahl von Erkrankungen rücken zunehmend in den Fokus der modernen Arzneimittelforschung. Insbesondere selektive Histone Deacetylase Inhibitoren (HDACi) bieten hier interessante Möglichkeiten. Da ferner in einem Tiermodell unter Deletion der HDAC6 Genexpression keine Beeinträchtigung der ...

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Translation of the abstract (English)

Histone deacetylase inhibitors (HDACi) respresent new drugs for the therapy of diseases like autoimmunity, cancer and inflammation. To minimize the broad spectrum of side effects, the focus of this work was to synthesize an isoform specific histone deacetylase 6 inhibitor (HDAC6i) containing an hydroxamic acid moiety linked to tetrahydro-β-carboline. Marbostat-100 is a very selective and potent ...

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