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N‑Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis
Wimmer, Alexander and König, Burkhard
(2019)
N‑Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis.
Organic Letters 21, pp. 2740-2744.
Date of publication of this fulltext: 15 Apr 2019 13:22
Article
DOI to cite this document: 10.5283/epub.40076
Abstract
The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group ...
The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group tolerance. In addition, we could demonstrate that other sulfoximidoyl derivatives like sulfonimidamides and sulfinamides proceed smoothly under the developed reaction conditions.
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Details
| Item type | Article | ||||
| Journal or Publication Title | Organic Letters | ||||
| Publisher: | AMER CHEMICAL SOC | ||||
|---|---|---|---|---|---|
| Place of Publication: | WASHINGTON | ||||
| Volume: | 21 | ||||
| Page Range: | pp. 2740-2744 | ||||
| Date | 2019 | ||||
| Institutions | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König | ||||
| Identification Number |
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| Keywords | ARYL IODIDES; LIGANDS; PHOTOREDOX; | ||||
| Dewey Decimal Classification | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-400763 | ||||
| Item ID | 40076 |
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