N‑Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis

URN to cite this document:: urn:nbn:de:bvb:355-epub-400763
DOI to cite this document:: 10.5283/epub.40076

Wimmer, Alexander ; König, Burkhard

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Date of publication of this fulltext: 15 Apr 2019 13:22

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Abstract

The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group ...