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N‑Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis
Wimmer, Alexander und König, Burkhard
(2019)
N‑Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis.
Organic Letters 21, S. 2740-2744.
Veröffentlichungsdatum dieses Volltextes: 15 Apr 2019 13:22
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.40076
Zusammenfassung
The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group ...
The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group tolerance. In addition, we could demonstrate that other sulfoximidoyl derivatives like sulfonimidamides and sulfinamides proceed smoothly under the developed reaction conditions.
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| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | Organic Letters | ||||
| Verlag: | AMER CHEMICAL SOC | ||||
|---|---|---|---|---|---|
| Ort der Veröffentlichung: | WASHINGTON | ||||
| Band: | 21 | ||||
| Seitenbereich: | S. 2740-2744 | ||||
| Datum | 2019 | ||||
| Institutionen | Chemie und Pharmazie > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König | ||||
| Identifikationsnummer |
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| Stichwörter / Keywords | ARYL IODIDES; LIGANDS; PHOTOREDOX; | ||||
| Dewey-Dezimal-Klassifikation | 500 Naturwissenschaften und Mathematik > 540 Chemie 600 Technik, Medizin, angewandte Wissenschaften > 615 Pharmazie | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Ja | ||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-400763 | ||||
| Dokumenten-ID | 40076 |
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