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Wimmer, Alexander ; König, Burkhard

N‑Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis

Wimmer, Alexander and König, Burkhard (2019) N‑Arylation of NH-Sulfoximines via Dual Nickel Photocatalysis. Organic Letters 21, pp. 2740-2744.

Date of publication of this fulltext: 15 Apr 2019 13:22
Article
DOI to cite this document: 10.5283/epub.40076


Abstract

The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group ...

The pharmaceutically underexplored sulfoximine moiety has emerged as a potentially active pharmaceutical ingredient. We developed a scalable synthetic route to N-arylated sulfoximines from the respective "free" NH-sulfoximines and bromoarenes. Our strategy is based on a dual nickel photocatalytic approach, is applicable for a broad scope of substrates, and exhibits a highly functional group tolerance. In addition, we could demonstrate that other sulfoximidoyl derivatives like sulfonimidamides and sulfinamides proceed smoothly under the developed reaction conditions.



Involved Institutions


Details

Item typeArticle
Journal or Publication TitleOrganic Letters
Publisher:AMER CHEMICAL SOC
Place of Publication:WASHINGTON
Volume:21
Page Range:pp. 2740-2744
Date2019
InstitutionsChemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Identification Number
ValueType
10.1021/acs.orglett.9b00698DOI
KeywordsARYL IODIDES; LIGANDS; PHOTOREDOX;
Dewey Decimal Classification500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-400763
Item ID40076

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