The C-terminal region of Net1 is an activator of RNA polymerase I transcription with conserved features from yeast to human

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urn:nbn:de:bvb:355-epub-401732 Copy

Hannig, Katharina ; Babl, Virginia ; Hergert, Kristin ; Maier, Andreas ; Pilsl, Michael ; Schächner, Christopher ; Stöckl, Ulrike ; Milkereit, Philipp ; Tschochner, Herbert ; Seufert, Wolfgang ; Griesenbeck, Joachim

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Date of publication of this fulltext: 03 May 2019 11:23

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Item type:	Article
Journal or Publication Title:	PLOS Genetics
Publisher:	Public Library of Science
Volume:	15
Number of Issue or Book Chapter:	2
Page Range:	e1008006
Date:	25 February 2019
Institutions:	Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Herbert Tschochner Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Dr. Joachim Griesenbeck Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Dr. Philipp Milkereit
Projects:	Open Access Publizieren (DFG)
Identification Number:	Value Type 10.1371/journal.pgen.1008006 DOI
Dewey Decimal Classification:	500 Science > 570 Life sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	40173

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Abstract

RNA polymerase I (Pol I) synthesizes ribosomal RNA (rRNA) in all eukaryotes, accounting for the major part of transcriptional activity in proliferating cells. Although basal Pol I transcription factors have been characterized in diverse organisms, the molecular basis of the robust rRNA production in vivo remains largely unknown. In S. cerevisiae, the multifunctional Net1 protein was reported to ...

Abstract

RNA polymerase I (Pol I) synthesizes ribosomal RNA (rRNA) in all eukaryotes, accounting for the major part of transcriptional activity in proliferating cells. Although basal Pol I transcription factors have been characterized in diverse organisms, the molecular basis of the robust rRNA production in vivo remains largely unknown. In S. cerevisiae, the multifunctional Net1 protein was reported to stimulate Pol I transcription. We found that the Pol I-stimulating function can be attributed to the very C-terminal region (CTR) of Net1. The CTR was required for normal cell growth and Pol I recruitment to rRNA genes in vivo and sufficient to promote Pol I transcription in vitro. Similarity with the acidic tail region of mammalian Pol I transcription factor UBF, which could partly functionally substitute for the CTR, suggests conserved roles for CTR-like domains in Pol I transcription from yeast to human.

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