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The C-terminal region of Net1 is an activator of RNA polymerase I transcription with conserved features from yeast to human

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Hannig, Katharina ; Babl, Virginia ; Hergert, Kristin ; Maier, Andreas ; Pilsl, Michael ; Schächner, Christopher ; Stöckl, Ulrike ; Milkereit, Philipp ; Tschochner, Herbert ; Seufert, Wolfgang ; Griesenbeck, Joachim
Date of publication of this fulltext: 03 May 2019 11:23


RNA polymerase I (Pol I) synthesizes ribosomal RNA (rRNA) in all eukaryotes, accounting for the major part of transcriptional activity in proliferating cells. Although basal Pol I transcription factors have been characterized in diverse organisms, the molecular basis of the robust rRNA production in vivo remains largely unknown. In S. cerevisiae, the multifunctional Net1 protein was reported to ...


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