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Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations

Berger, Raffaela S., Ellmann, Lisa, Reinders, Joerg, Kreutz, Marina, Stempfl, Thomas, Oefner, Peter J. and Dettmer, Katja (2019) Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations. Scientific Reports 9 (1), pp. 1-11.

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Date of publication of this fulltext: 03 Jul 2019 15:14

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Other URL: http://doi.org/10.1038/s41598-019-43891-3


Abstract

D-2-Hydroxyglutarate (D-2-HG) is regarded as an oncometabolite. It is found at elevated levels in certain malignancies such as acute myeloid leukaemia and glioma. It is produced by a mutated isocitrate dehydrogenase IDH1/2, a low-affinity/high-capacity enzyme. Its degradation, in contrast, is catalysed by the high-affinity/low-capacity enzyme D-2-hydroxyglutarate dehydrogenase (D2HDH). So far, it ...

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Item type:Article
Date:15 May 2019
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/s41598-019-43891-3DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40443
Owner only: item control page

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