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Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations

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Berger, Raffaela S. ; Ellmann, Lisa ; Reinders, Joerg ; Kreutz, Marina ; Stempfl, Thomas ; Oefner, Peter J. ; Dettmer, Katja
Date of publication of this fulltext: 03 Jul 2019 15:14


D-2-Hydroxyglutarate (D-2-HG) is regarded as an oncometabolite. It is found at elevated levels in certain malignancies such as acute myeloid leukaemia and glioma. It is produced by a mutated isocitrate dehydrogenase IDH1/2, a low-affinity/high-capacity enzyme. Its degradation, in contrast, is catalysed by the high-affinity/low-capacity enzyme D-2-hydroxyglutarate dehydrogenase (D2HDH). So far, it ...


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