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TRAIL induces nuclear translocation and chromatin localization of TRAIL death receptors

URN to cite this document:
urn:nbn:de:bvb:355-epub-415776
Mert, U. ; Adawy, A. ; Scharff, E. ; Fritsch, Jürgen
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Date of publication of this fulltext: 13 Feb 2020 10:03


Abstract

Binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to the plasma membrane TRAIL-R1/-R2 selectively kills tumor cells. This discovery led to evaluation of TRAIL-R1/-R2 as targets for anti-cancer therapy, yet the corresponding clinical trials were disappointing. Meanwhile, it emerged that many cancer cells are TRAIL-resistant and that TRAIL-R1/-R2-triggering may lead to ...

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