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Novel population pharmacokinetic approach to explain the differences between cystic fibrosis patients and healthy volunteers via protein binding

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Shah, Nirav R. ; Bulitta, J. B. ; Kinzig, M. ; Kees, Frieder ; ; ; ; ; ; ; ;
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 14 Feb 2020 13:41


The pharmacokinetics in patients with cystic fibrosis (CF) has long been thought to differ considerably from that in healthy volunteers. For highly protein bound beta -lactams, profound pharmacokinetic differences were observed between comparatively morbid patients with CF and healthy volunteers. These differences could be explained by body weight and body composition for beta -lactams with low ...


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