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Häring, Marleen ; Schiller, Jana ; Mayr, Judith ; Diaz Diaz, David

Magnetic Gel Composites for Hyperthermia Cancer Therapy

Häring, Marleen, Schiller, Jana, Mayr, Judith und Diaz Diaz, David (2015) Magnetic Gel Composites for Hyperthermia Cancer Therapy. Gels 1, S. 135-161.

Veröffentlichungsdatum dieses Volltextes: 17 Feb 2020 10:19
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.41625


Zusammenfassung

Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological (i.e., between 41 and 46 °C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anti-cancer drugs. Among several methods suitable for heating tumor areas, magnetic hyperthermia involves the introduction of magnetic ...

Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological (i.e., between 41 and 46 °C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anti-cancer drugs. Among several methods suitable for heating tumor areas, magnetic hyperthermia involves the introduction of magnetic micro/nanoparticles into the tumor tissue, followed by the application of an external magnetic field at fixed frequency and amplitude. A very interesting approach for magnetic hyperthermia is the use of biocompatible thermo-responsive magnetic gels made by the incorporation of the magnetic particles into cross-linked polymer gels. Mainly because of the hysteresis loss from the magnetic particles subjected to a magnetic field, the temperature of the system goes up and, once the temperature crosses the lower critical solution temperature, thermo-responsive gels undergo large volume changes and may deliver anti-cancer drug molecules that have been previously entrapped in their networks. This tutorial review describes the main properties and formulations of magnetic gel composites conceived for magnetic hyperthermia therapy.



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Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftGels
Verlag:Molecular Diversity Preservation International (MDPI)
Band:1
Seitenbereich:S. 135-161
Datum2015
InstitutionenChemie und Pharmazie > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz
Identifikationsnummer
WertTyp
10.3390/gels1020135DOI
Stichwörter / Keywordshydrogel; composites; magnetic nanoparticles; hyperthermia; cancer therapy; drug delivery
Dewey-Dezimal-Klassifikation500 Naturwissenschaften und Mathematik > 540 Chemie
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-416258
Dokumenten-ID41625

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