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Magnetic Gel Composites for Hyperthermia Cancer Therapy
Häring, Marleen, Schiller, Jana, Mayr, Judith und Diaz Diaz, David (2015) Magnetic Gel Composites for Hyperthermia Cancer Therapy. Gels 1, S. 135-161.Veröffentlichungsdatum dieses Volltextes: 17 Feb 2020 10:19
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.41625
Zusammenfassung
Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological (i.e., between 41 and 46 °C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anti-cancer drugs. Among several methods suitable for heating tumor areas, magnetic hyperthermia involves the introduction of magnetic ...
Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological (i.e., between 41 and 46 °C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anti-cancer drugs. Among several methods suitable for heating tumor areas, magnetic hyperthermia involves the introduction of magnetic micro/nanoparticles into the tumor tissue, followed by the application of an external magnetic field at fixed frequency and amplitude. A very interesting approach for magnetic hyperthermia is the use of biocompatible thermo-responsive magnetic gels made by the incorporation of the magnetic particles into cross-linked polymer gels. Mainly because of the hysteresis loss from the magnetic particles subjected to a magnetic field, the temperature of the system goes up and, once the temperature crosses the lower critical solution temperature, thermo-responsive gels undergo large volume changes and may deliver anti-cancer drug molecules that have been previously entrapped in their networks. This tutorial review describes the main properties and formulations of magnetic gel composites conceived for magnetic hyperthermia therapy.
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Details
| Dokumentenart | Artikel | ||||
| Titel eines Journals oder einer Zeitschrift | Gels | ||||
| Verlag: | Molecular Diversity Preservation International (MDPI) | ||||
|---|---|---|---|---|---|
| Band: | 1 | ||||
| Seitenbereich: | S. 135-161 | ||||
| Datum | 2015 | ||||
| Institutionen | Chemie und Pharmazie > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz | ||||
| Identifikationsnummer |
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| Stichwörter / Keywords | hydrogel; composites; magnetic nanoparticles; hyperthermia; cancer therapy; drug delivery | ||||
| Dewey-Dezimal-Klassifikation | 500 Naturwissenschaften und Mathematik > 540 Chemie | ||||
| Status | Veröffentlicht | ||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden | Ja | ||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-416258 | ||||
| Dokumenten-ID | 41625 |
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