Thermodynamic, Spatial and Methodological Considerations for the Manufacturing of Therapeutic Polymer Nanoparticles

URN to cite this document:: urn:nbn:de:bvb:355-epub-416878
DOI to cite this document:: 10.5283/epub.41687

Goepferich, Achim

; Maslanka-Figueroa, Sara ; Fleischmann, Daniel ; Beck, Sebastian

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Date of publication of this fulltext: 26 Feb 2020 09:01

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Abstract

Purpose Evaluate fundamental parameters that dictate the effectiveness of drug loading. Methods A model water-soluble drug lacking ionizable groups, pirfenidone (PFD), was encapsulated through nanoprecipitation in poly(ethylene glycol)-poly(lactic acid) (PEG-PLA)-poly(lactic-co-glycolic acid) (PLGA) NPs. Firstly, the thermodynamic parameters predicting drug-polymer miscibility were determined to ...