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Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells

Kariminia, Amina ; Holtan, Shernan G. ; Ivison, Sabine ; Rozmus, Jacob ; Hebert, Marie-Josée ; Martin, Paul J. ; Lee, Stephanie J. ; Wolff, Daniel ; Subrt, Peter ; Abdossamadi, Sayeh ; Sung, Susanna ; Storek, Jan ; Levings, Megan ; Aljurf, Mahmoud ; Arora, Mukta ; Cutler, Corey ; Gallagher, Geneviève ; Kuruvilla, John ; Lipton, Jeff ; Nevill, Thomas J. ; Newell, Laura F. ; Panzarella, Tony ; Pidala, Joseph ; Popradi, Gizelle ; Szwajcer, David ; Tay, Jason ; Toze, Cynthia L. ; Walker, Irwin ; Couban, Stephen ; Storer, Barry E. ; Schultz, Kirk R.



Abstract

Chronic graft-versus-host disease(cGVHD) remains one of the most significant long-term complications after allogeneic blood and marrow transplantation. Diagnostic biomarkers for cGVHD are needed for early diagnosis and may guide identification of prognostic markers. No cGVHD biomarker has yet been validated for use in clinical practice. We evaluated both previously known markers and performed ...

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