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Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting

Pilsl, Michael ; Engel, Christoph
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Date of publication of this fulltext: 09 Apr 2020 16:33


Abstract

Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a prerequisite for the biosynthesis of ribosomes in eukaryotes. Compared to Pols II and III, the mechanisms underlying promoter recognition, initiation complex formation and DNA melting by Pol I substantially diverge. Here, we report the high-resolution cryo-EM reconstruction of a Pol I early initiation intermediate ...

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