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Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics

Schießer, Selina ; Hitzenbichler, Florian ; Kees, Martin Georg ; Kratzer, Alexander ; Lubnow, Matthias ; Salzberger, Bernd ; Kees, Frieder ; Dorn, Christoph


Objective: To assess the applicability of an ultrafiltration method to determine free plasma concentrations of beta-lactam antibiotics in ICU patients. Patients and methods: Eligible patients included adult ICU patients treated with ceftazidime (CAZ), meropenem (MEM), piperacillin/tazobactam (PIP/TAZ), or flucloxacillin (FXN) by continuous infusion. Up to two arterial blood samples were drawn at ...


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