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Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death

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Luger, Anna-Luisa ; Lorenz, Nadja I. ; Urban, Hans ; Divé, Iris ; Engel, Anna L. ; Strassheimer, Florian ; Dettmer, Katja ; Zeiner, Pia S. ; Shaid, Shabnam ; Struve, Nina ; Kriegs, Malte ; Hofmann, Ute ; Oefner, Peter J. ; Harter, Patrick N. ; Steinbach, Joachim P. ; Ronellenfitsch, Michael W.
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 01 Dec 2020 07:51


Background: The epidermal growth factor receptor (EGFR) signaling pathway is genetically activated in approximately 50% of glioblastomas (GBs). Its inhibition has been explored clinically but produced disappointing results, potentially due to metabolic effects that protect GB cells against nutrient deprivation and hypoxia. Here, we hypothesized that EGFR activation could disable metabolic ...


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