GDF15 promotes simultaneous astrocyte remodeling and tight junction strengthening at the blood–brain barrier

URN to cite this document:: urn:nbn:de:bvb:355-epub-452413
DOI to cite this document:: 10.5283/epub.45241

Malik, Victoria A. ; Zajicek, Franziska ; Mittmann, Laura A. ; Klaus, Johannes ; Unterseer, Sandra ; Rajkumar, Sandeep ; Pütz, Benno ; Deussing, Jan M. ; Neumann, Inga D.

; Rupprecht, Rainer ; Di Benedetto, Barbara

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Date of publication of this fulltext: 19 Mar 2021 05:28

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Abstract

Perivascular astrocyte processes (PAP) surround cerebral endothelial cells (ECs) and modulate the strengthening of tight junctions to influence blood-brain barrier (BBB) permeability. Morphologically altered astrocytes may affect barrier properties and trigger the onset of brain pathologies. However, astrocyte-dependent mediators of these events remain poorly studied. Here, we show a ...