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GDF15 promotes simultaneous astrocyte remodeling and tight junction strengthening at the blood–brain barrier

Malik, Victoria A. ; Zajicek, Franziska ; Mittmann, Laura A. ; Klaus, Johannes ; Unterseer, Sandra ; Rajkumar, Sandeep ; Pütz, Benno ; Deussing, Jan M. ; Neumann, Inga D. ; Rupprecht, Rainer ; Di Benedetto, Barbara



Abstract

Perivascular astrocyte processes (PAP) surround cerebral endothelial cells (ECs) and modulate the strengthening of tight junctions to influence blood–brain barrier (BBB) permeability. Morphologically altered astrocytes may affect barrier properties and trigger the onset of brain pathologies. However, astrocyte‐dependent mediators of these events remain poorly studied. Here, we show a ...

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