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GDF15 promotes simultaneous astrocyte remodeling and tight junction strengthening at the blood–brain barrier

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Malik, Victoria A. ; Zajicek, Franziska ; Mittmann, Laura A. ; Klaus, Johannes ; Unterseer, Sandra ; Rajkumar, Sandeep ; Pütz, Benno ; Deussing, Jan M. ; Neumann, Inga D. ; Rupprecht, Rainer ; Di Benedetto, Barbara
Date of publication of this fulltext: 19 Mar 2021 05:28

This publication is part of the DEAL contract with Wiley.


Perivascular astrocyte processes (PAP) surround cerebral endothelial cells (ECs) and modulate the strengthening of tight junctions to influence blood-brain barrier (BBB) permeability. Morphologically altered astrocytes may affect barrier properties and trigger the onset of brain pathologies. However, astrocyte-dependent mediators of these events remain poorly studied. Here, we show a ...


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