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Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling

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Peters, Sebastian ; Kuespert, Sabrina ; Wirkert, Eva ; Heydn, Rosmarie ; Jurek, Benjamin ; Johannesen, Siw ; Hsam, Ohnmar ; Korte, Sven ; Ludwig, Florian Timo ; Mecklenburg, Lars ; Mrowetz, Heike ; Altendorfer, Barbara ; Poupardin, Rodolphe ; Petri, Susanne ; Thal, Dietmar R. ; Hermann, Andreas ; Weishaupt, Jochen H. ; Weis, Joachim ; Aksoylu, Inci Sevval ; Lewandowski, Sebastian A. ; Aigner, Ludwig ; Bruun, Tim-Henrik ; Bogdahn, Ulrich
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Apr 2021 08:31

This publication is part of the DEAL contract with Springer.


Adult neurogenesis is a target for brain rejuvenation as well as regeneration in aging and disease. Numerous approaches showed efficacy to elevate neurogenesis in rodents, yet translation into therapies has not been achieved. Here, we introduce a novel human TGF beta-RII (Transforming Growth Factor-Receptor Type II) specific LNA-antisense oligonucleotide ("locked nucleotide acid"-"NVP-13"), which ...


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