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Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling

URN to cite this document:
urn:nbn:de:bvb:355-epub-455608
DOI to cite this document:
10.5283/epub.45560
Peters, Sebastian ; Kuespert, Sabrina ; Wirkert, Eva ; Heydn, Rosmarie ; Jurek, Benjamin ; Johannesen, Siw ; Hsam, Ohnmar ; Korte, Sven ; Ludwig, Florian Timo ; Mecklenburg, Lars ; Mrowetz, Heike ; Altendorfer, Barbara ; Poupardin, Rodolphe ; Petri, Susanne ; Thal, Dietmar R. ; Hermann, Andreas ; Weishaupt, Jochen H. ; Weis, Joachim ; Aksoylu, Inci Sevval ; Lewandowski, Sebastian A. ; Aigner, Ludwig ; Bruun, Tim-Henrik ; Bogdahn, Ulrich
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Apr 2021 08:31

This publication is part of the DEAL contract with Springer.


Abstract

Adult neurogenesis is a target for brain rejuvenation as well as regeneration in aging and disease. Numerous approaches showed efficacy to elevate neurogenesis in rodents, yet translation into therapies has not been achieved. Here, we introduce a novel human TGFβ-RII (Transforming Growth Factor—Receptor Type II) specific LNA-antisense oligonucleotide (“locked nucleotide acid”—“NVP-13”), which ...

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