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Learning from Embryogenesis—A Comparative Expression Analysis in Melanoblast Differentiation and Tumorigenesis Reveals miRNAs Driving Melanoma Development

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Linck-Paulus, Lisa ; Lämmerhirt, Lisa ; Völler, Daniel ; Meyer, Katharina ; Engelmann, Julia C. ; Spang, Rainer ; Eichner, Norbert ; Meister, Gunter ; Kuphal, Silke ; Bosserhoff, Anja Katrin
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 31 May 2021 10:16


Malignant melanoma is one of the most dangerous tumor types due to its high metastasis rates and a steadily increasing incidence. During tumorigenesis, the molecular processes of embryonic development, exemplified by epithelial-mesenchymal transition (EMT), are often reactivated. For melanoma development, the exact molecular differences between melanoblasts, melanocytes, and melanoma cells are ...


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