Learning from Embryogenesis—A Comparative Expression Analysis in Melanoblast Differentiation and Tumorigenesis Reveals miRNAs Driving Melanoma Development

URN to cite this document:: urn:nbn:de:bvb:355-epub-458891
DOI to cite this document:: 10.5283/epub.45889

Linck-Paulus, Lisa

; Lämmerhirt, Lisa ; Völler, Daniel ; Meyer, Katharina ; Engelmann, Julia C.

; Spang, Rainer ; Eichner, Norbert ; Meister, Gunter ; Kuphal, Silke ; Bosserhoff, Anja Katrin

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Date of publication of this fulltext: 31 May 2021 10:16

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Abstract

Malignant melanoma is one of the most dangerous tumor types due to its high metastasis rates and a steadily increasing incidence. During tumorigenesis, the molecular processes of embryonic development, exemplified by epithelial-mesenchymal transition (EMT), are often reactivated. For melanoma development, the exact molecular differences between melanoblasts, melanocytes, and melanoma cells are ...