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Virus-specific memory T cell responses unmasked by immune checkpoint blockade cause hepatitis

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Hutchinson, James A. ; Kronenberg, Katharina ; Riquelme, Paloma ; Wenzel, Jürgen J. ; Glehr, Gunther ; Schilling, Hannah-Lou ; Zeman, Florian ; Evert, Katja ; Schmiedel, Martin ; Mickler, Marion ; Drexler, Konstantin ; Bitterer, Florian ; Cordero, Laura ; Beyer, Lukas Philipp ; Bach, Christian ; Koestler, Josef ; Burkhardt, Ralph ; Schlitt, Hans J. ; Hellwig, Dirk ; Werner, Jens M. ; Spang, Rainer ; Schmidt, Barbara ; Geissler, Edward K. ; Haferkamp, Sebastian
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Jul 2021 18:09


Treatment of advanced melanoma with combined PD-1/CTLA-4 blockade commonly causes serious immune-mediated complications. Here, we identify a subset of patients predisposed to immune checkpoint blockade-related hepatitis who are distinguished by chronic expansion of effector memory CD4(+) T cells (T-EM cells). Pre-therapy CD4(+) T-EM cell expansion occurs primarily during autumn or winter in ...


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