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The tumor-inhibiting effect of isomeric dichloro(diphenylethylenediamine)platinum(II) complexes

Wappes, B. ; Jennerwein, M. ; Angerer, E. von ; Engel, J. ; Schönenberger, H. ; Brunner, H. ; Schmidt, M. ; Berger, M. ; Schmähl, D. ; Seeber, S.



Abstract

Ring unsubstituted dichloro(diphenylethylenediamine)platinum(II) complexes show a dependence of their antitumor activity on the configuration and position of phenyl rings in ethylenediamine ligand. Dichloro(1,1-diphenylethylenediamine)platinum(II) (1d) and meso-dichloro(1,2-diphenylethylenediamine)-platinum(II) (meso-2d) have a weaker effect on the human breast-cancer cell line MDA-MB 231 and on ...

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