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Coarse particulate matter (PM2.5–10) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains

Ljubimova, Julia Y. ; Braubach, Oliver ; Patil, Rameshwar ; Chiechi, Antonella ; Tang, Jie ; Galstyan, Anna ; Shatalova, Ekaterina S. ; Kleinman, Michael T. ; Black, Keith L. ; Holler, Eggehard



Abstract

Air pollution is linked to brain inflammation, which accelerates tumorigenesis and neurodegeneration. The molecular mechanisms that connect air pollution with brain pathology are largely unknown but seem to depend on the chemical composition of airborne particulate matter (PM). We sourced ambient PM from Riverside, California, and selectively exposed rats to coarse (PM2.5-10: 2.5-10 mu m), fine ...

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