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1-(aminoalkyl)-2-phenylindoles as novel pure estrogen antagonists

Angerer, E. von ; Knebel, N. ; Kager, M. ; Ganss, B.


A number of 1-(omega-aminoalkyl)-5-hydroxy-2-(4-hydroxyphenyl)indoles were synthesized and studied for their binding affinities for the calf uterine estrogen receptor and estrogen antagonistic activities. Highest binding affinities were found with derivatives bearing a methyl group in position 3 and a hexamethylene chain between the indole and amino nitrogen atoms. Values for relative binding ...


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