Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-47664

Angerer, S. von ; Seidl, E. ; Mannschreck, A. ; Angerer, E. von ; Wiegrebe, Wolfgang

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Date of publication of this fulltext: 05 Aug 2009 13:48

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Abstract

A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring closure reaction involving a base-generated benzyne intermediate. The methoxy functions in positions 2 or 3 and 9 were cleaved with BBr3 and the free ...