Chemosensitivity of human MCF-7 breast cancer cells to diastereoisomeric diaqua(1,2-diphenylethylenediamine) platinum(II) sulfates and specific platinum accumulation

URN to cite this document:: urn:nbn:de:bvb:355-epub-48309
DOI to cite this document:: 10.5283/epub.4830

Reile, Herta ; Bernhardt, Günther ; Koch, Marion ; Schönenberger, Helmut ; Hollstein, Michael ; Lux, Franz

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Date of publication of this fulltext: 05 Aug 2009 13:48

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Abstract

Cisplatin, raceme-diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]platinu m(II) sulfate (compound I), meso-diaqua[1,2-bis(4-fluorophenyl)ethylenediamine]-platinum(II) sulfate (compound II), and meso-diaqua[1,2-bis(2,6-dichloro-4- hydroxyphenyl)ethylenediamine]platinum(II) sulfate (compound III) were compared with regard to their effect on the MCF-7 breast cancer cell line in vitro. At equimolar ...