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Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. Part II: Biological evaluation-in vitro studies on the P 388 D1 leukemia cell line

Reile, Herta, Müller, Richard, Gust, Ronald, Laske, Reiner, Krischke, Walter, Bernhardt, Günther, Spruss, Thilo, Jennerwein, Margaretha, Engel, Jürgen and Seeber, Siegfried (1990) Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. Part II: Biological evaluation-in vitro studies on the P 388 D1 leukemia cell line. Archiv der Pharmazie 323 (3), pp. 133-140.

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Abstract

Experiments on the P 388 D1 cell line (48 h exposure) demonstrate that [1,2-bis-(fluorophenyl)ethylenediamine]platinum(II) complexes are comparably active on the cell number and 3H-thymidine incorporation, irrespective of the position of the fluorine atom (ortho, meta, or para) and the nature of the "leaving group" (Cl- or H2O). However, the compounds of the R,R/S,S series are more active than ...

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Item type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
ValueType
2344259PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/pharmacologyMESH
Cell Survival/drug effectsMESH
Cisplatin/pharmacologyMESH
Leukemia P388/pathologyMESH
Leukemia, Experimental/pathologyMESH
MiceMESH
Organoplatinum Compounds/pharmacologyMESH
Tumor Cells, Cultured/drug effectsMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:4832
Owner only: item control page

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