Tumor inhibiting [1,2-bis(fluorophenyl)ethylenediamine]platinum(II) complexes. Part II: Biological evaluation-in vitro studies on the P 388 D1 leukemia cell line

URN to cite this document:: urn:nbn:de:bvb:355-epub-48329
DOI to cite this document:: 10.5283/epub.4832

Reile, Herta ; Müller, Richard ; Gust, Ronald ; Laske, Reiner ; Krischke, Walter ; Bernhardt, Günther ; Spruss, Thilo ; Jennerwein, Margaretha ; Engel, Jürgen ; Seeber, Siegfried

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Date of publication of this fulltext: 05 Aug 2009 13:48

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Abstract

Experiments on the P 388 D1 cell line (48 h exposure) demonstrate that [1,2-bis-(fluorophenyl)ethylenediamine]platinum(II) complexes are comparably active on the cell number and 3H-thymidine incorporation, irrespective of the position of the fluorine atom (ortho, meta, or para) and the nature of the "leaving group" (Cl- or H2O). However, the compounds of the R,R/S,S series are more active than ...