| Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | European Journal of Nuclear Medicine and Molecular Imaging | ||||
| Verlag: | SPRINGER | ||||
| Ort der Veröffentlichung: | NEW YORK | ||||
| Band: | 46 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 3 | ||||
| Seitenbereich: | S. 580-590 | ||||
| Datum: | 2019 | ||||
| Institutionen: | Medizin > Lehrstuhl für Psychiatrie und Psychotherapie | ||||
| Identifikationsnummer: |
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| Stichwörter / Keywords: | POSITRON-EMISSION-TOMOGRAPHY; TRANSLOCATOR PROTEIN; TSPO-PET; RESPONSE ASSESSMENT; BINDING; EXPRESSION; LIGAND; MODEL; BRAIN; NEUROINFLAMMATION; F-18-GE-180; TSPO; F-18-FET; Amino acid; MRI; High-grade glioma | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 48958 |
Web of ScienceZusammenfassung
BackgroundPET represents a valuable tool for glioma imaging. In addition to amino acid tracers such as F-18-FET, PET targeting the 18-kDa mitochondrial translocator-protein (TSPO) is of high interest for high-grade glioma (HGG) imaging due to its upregulation in HGG cells. F-18-GE-180, a novel TSPO ligand, has shown a high target-to-background contrast in HGG. Therefore, we intra-individually ...
Zusammenfassung
BackgroundPET represents a valuable tool for glioma imaging. In addition to amino acid tracers such as F-18-FET, PET targeting the 18-kDa mitochondrial translocator-protein (TSPO) is of high interest for high-grade glioma (HGG) imaging due to its upregulation in HGG cells. F-18-GE-180, a novel TSPO ligand, has shown a high target-to-background contrast in HGG. Therefore, we intra-individually compared its uptake characteristics to dynamic F-18-FET PET and contrast-enhanced MRI in patients with HGG.MethodsTwenty HGG patients (nine IDH-wildtype, 11 IDH-mutant) at initial diagnosis (n=8) or recurrence (n=12) were consecutively included and underwent F-18-GE-180 PET, dynamic F-18-FET PET, and MRI. The maximal tumour-to-background ratios (TBRmax) and biological tumour volumes (BTV) were evaluated in F-18-GE-180 and F-18-FET PET. Dynamic F-18-FET PET analysis included the evaluation of minimal time-to-peak (TTPmin). In MRI, the volume of contrast-enhancement was delineated (VOLCE). Volumes were spatially correlated using the SOrensen-Dice coefficient.ResultsThe median TBRmax tended to be higher in F-18-GE-180 PET compared to F-18-FET PET [4.58 (2.33-8.95) vs 3.89 (1.56-7.15); p=0.062] in the overall group. In subgroup analyses, IDH-wildtype gliomas showed a significantly higher median TBRmax in F-18-GE-180 PET compared to F-18-FET PET [5.45 (2.56-8.95) vs 4.06 (1.56-4.48); p=0.008]; by contrast, no significant difference was observed in IDH-mutant gliomas [3.97 (2.33-6.81) vs 3.79 (2.01-7.15) p=1.000]. Only 5/20 cases showed higher TBRmax in F-18-FET PET compared to F-18-GE-180 PET, all of them being IDH-mutant gliomas. No parameter in F-18-GE-180 PET correlated with TTPmin (p>0.05 each). There was a tendency towards higher median BTVGE-180 [32.1 (0.4-236.0) ml] compared to BTVFET [19.3 (0.7-150.2) ml; p=0.062] with a moderate spatial overlap [median SOrensen-Dice coefficient 0.55 (0.07-0.85)]. In MRI, median VOLCE [9.7 (0.1-72.5) ml] was significantly smaller than both BTVFET and BTVGE180 (p<0.001 each), leading to a poor spatial correlation with BTVGE-180 [0.29 (0.01-0.48)] and BTVFET [0.38 (0.01-0.68)].ConclusionPET with F-18-GE-180 and F-18-FET provides differing imaging information in HGG dependent on the IDH-mutational status, with diverging spatial overlap and vast exceedance of contrast-enhancement in MRI. Combined PET imaging might reveal new insights regarding non-invasive characterization of tumour heterogeneity and might influence patients' management.
Metadaten zuletzt geändert: 03 Sep 2021 10:04
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