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Comparison of 18F-GE-180 and dynamic 18F-FET PET in high grade glioma: a double-tracer pilot study

Unterrainer, Marcus ; Fleischmann, D. F. ; Diekmann, C. ; Vomacka, L. ; Lindner, S. ; Vettermann, F. ; Brendel, M. ; Wenter, V. ; Ertl-Wagner, B. ; Herms, J. ; Wetzel, C. ; Rupprecht, R. ; Tonn, J. C. ; Belka, C. ; Bartenstein, P. ; Niyazi, M. ; Albert, Nathalie L.



Abstract

BackgroundPET represents a valuable tool for glioma imaging. In addition to amino acid tracers such as F-18-FET, PET targeting the 18-kDa mitochondrial translocator-protein (TSPO) is of high interest for high-grade glioma (HGG) imaging due to its upregulation in HGG cells. F-18-GE-180, a novel TSPO ligand, has shown a high target-to-background contrast in HGG. Therefore, we intra-individually ...

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