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Controlling Enzymatic Activity by Modulating the Oligomerization State via Chemical Rescue and Optical Control

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Kropp, Cosimo ; Bruckmann, Astrid ; Babinger, Patrick
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 Oct 2021 09:21

This publication is part of the DEAL contract with Wiley.


Selective switching of enzymatic activity has been a longstanding goal in synthetic biology. Drastic changes in activity upon mutational manipulation of the oligomerization state of enzymes have frequently been reported in the literature, but scarcely exploited for switching. Using geranylgeranylglyceryl phosphate synthase as a model, we demonstrate that catalytic activity can be efficiently ...


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