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Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

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Islam, M. M. Towhidul ; Tarnowski, Daniel ; Zhang, Min ; Trum, Maximilian ; Lebek, Simon ; Mustroph, Julian ; Daniel, Henriette ; Moellencamp, Johanna ; Pabel, Steffen ; Sossalla, Samuel ; El‐Armouche, Ali ; Nikolaev, Viacheslav O. ; Shah, Ajay M. ; Eaton, Philip J. ; Maier, Lars S. ; Sag, Can Martin ; Wagner, Stefan
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 14 Feb 2022 18:18


Background PKARI alpha (protein kinase A type I-alpha regulatory subunit) is redox-active independent of its physiologic agonist cAMP. However, it is unknown whether this alternative mechanism of PKARI alpha activation may be of relevance to cardiac excitation-contraction coupling. Methods and Results We used a redox-dead transgenic mouse model with homozygous knock-in replacement of ...


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