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Enhanced Heart Failure in Redox‐Dead Cys17Ser PKARIα Knock‐In Mice

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Islam, M. M. Towhidul ; Tarnowski, Daniel ; Zhang, Min ; Trum, Maximilian ; Lebek, Simon ; Mustroph, Julian ; Daniel, Henriette ; Moellencamp, Johanna ; Pabel, Steffen ; Sossalla, Samuel ; El‐Armouche, Ali ; Nikolaev, Viacheslav O. ; Shah, Ajay M. ; Eaton, Philip J. ; Maier, Lars S. ; Sag, Can Martin ; Wagner, Stefan
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 14 Feb 2022 18:18


Background PKARIα (protein kinase A type I‐α regulatory subunit) is redox‐active independent of its physiologic agonist cAMP. However, it is unknown whether this alternative mechanism of PKARIα activation may be of relevance to cardiac excitation–contraction coupling. Methods and Results We used a redox‐dead transgenic mouse model with homozygous knock‐in replacement of redox‐sensitive ...


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