Differential effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on startle response to predictable threat in a NPU-threat task after acute and short-term treatment

URN to cite this document:

urn:nbn:de:bvb:355-epub-519186 Copy

DOI to cite this document:

10.5283/epub.51918 Copy

Brunner, Lisa-Marie ; Maurer, Franziska ; Weber, Kevin ; Weigl, Johannes ; Milenkovic, Vladimir M. ; Rupprecht, Rainer ; Nothdurfter, Caroline ; Mühlberger, Andreas

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Date of publication of this fulltext: 15 Mar 2022 05:57

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Details

Item type:	Article
Journal or Publication Title:	Psychopharmacology
Publisher:	Springer
Date:	12 March 2022
Institutions:	Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Human Sciences > Institut für Psychologie > Lehrstuhl für Klinische Psychologie und Psychotherapie - Lehrstuhl für Psychologie VIII - Prof. Dr. Andreas Mühlberger
Projects:	DFG GRK 2174/1 — 2017
Identification Number:	Value Type 10.1007/s00213-022-06111-x DOI
Keywords:	GABAA receptor, Translocator protein 18 kDa (TSPO), NPU-threat task, Predictable threat, Unpredictable threat, Etifoxine, Alprazolam
Dewey Decimal Classification:	100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	51918

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Abstract

Rationale Benzodiazepines have been extensively investigated in experimental settings especially after single administration, which mostly revealed effects on unpredictable threat (U-threat) rather than predictable threat (P-threat). Given the need for pharmacological alternatives with a preferable side-effect profile and to better represent clinical conditions, research should cover also other ...

Abstract

Rationale
Benzodiazepines have been extensively investigated in experimental settings especially after single administration, which mostly revealed effects on unpredictable threat (U-threat) rather than predictable threat (P-threat). Given the need for pharmacological alternatives with a preferable side-effect profile and to better represent clinical conditions, research should cover also other anxiolytics and longer application times.
Objectives
The present study compared the acute and short-term effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on P-threat and U-threat while controlling for sedation.
Methods
Sixty healthy male volunteers, aged between 18 and 55 years, were randomly assigned to receive a daily dose of either 150 mg etifoxine, 1.5 mg alprazolam, or placebo for 5 days. On days 1 and 5 of intake, they performed a NPU-threat task including neutral (N), predictable (P), and unpredictable (U) conditions, while startle responsivity and self-reports were studied. Sedative effects were assessed using a continuous performance test.
Results
Neither alprazolam nor etifoxine affected startle responsivity to U-threat on any of the testing days. While etifoxine reduced the startle response to P-threat on day 1 of treatment for transformed data, a contrary effect of alprazolam was found for raw values. No effects on self-reports and no evidence of sedation could be observed for either drug.
Conclusions
None of the anxiolytic substances had an impact on startle potentiation to U-threat even after several days of intake. The effects of the anxiolytics on startle responsivity to P-threat as well as implications for future studies are discussed.

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Metadata last modified: 26 Jan 2023 07:19

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