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Differential effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on startle response to predictable threat in a NPU-threat task after acute and short-term treatment

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Brunner, Lisa-Marie ; Maurer, Franziska ; Weber, Kevin ; Weigl, Johannes ; Milenkovic, Vladimir M. ; Rupprecht, Rainer ; Nothdurfter, Caroline ; Mühlberger, Andreas
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Mar 2022 05:57

This publication is part of the DEAL contract with Springer.


Rationale Benzodiazepines have been extensively investigated in experimental settings especially after single administration, which mostly revealed effects on unpredictable threat (U-threat) rather than predictable threat (P-threat). Given the need for pharmacological alternatives with a preferable side-effect profile and to better represent clinical conditions, research should cover also other ...


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