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Differential effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on startle response to predictable threat in a NPU-threat task after acute and short-term treatment

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Brunner, Lisa-Marie ; Maurer, Franziska ; Weber, Kevin ; Weigl, Johannes ; Milenkovic, Vladimir M. ; Rupprecht, Rainer ; Nothdurfter, Caroline ; Mühlberger, Andreas
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 15 Mar 2022 05:57


Rationale Benzodiazepines have been extensively investigated in experimental settings especially after single administration, which mostly revealed effects on unpredictable threat (U-threat) rather than predictable threat (P-threat). Given the need for pharmacological alternatives with a preferable side-effect profile and to better represent clinical conditions, research should cover also other ...


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