| License: Creative Commons Attribution 4.0 PDF - Published Version (5MB) |
- URN to cite this document:
- urn:nbn:de:bvb:355-epub-524308
- DOI to cite this document:
- 10.5283/epub.52430
; Rasheed, Humaira
; Teumer, Alexander
; Gorski, Mathias ; Rowan, Bryce X.
; Stanzick, Kira J. ; Thomas, Laurent F. ; Tin, Adrienne
; Hoppmann, Anselm ; Chu, Audrey Y. ; Tayo, Bamidele ; Thio, Chris H. L. ; Cusi, Daniele
; Chai, Jin-Fang ; Sieber, Karsten B. ; Horn, Katrin ; Li, Man ; Scholz, Markus ; Cocca, Massimiliano
; Wuttke, Matthias ; van der Most, Peter J. ; Yang, Qiong ; Ghasemi, Sahar ; Nutile, Teresa ; Li, Yong ; Pontali, Giulia ; Günther, Felix ; Dehghan, Abbas ; Correa, Adolfo ; Parsa, Afshin ; Feresin, Agnese ; de Vries, Aiko P. J.
; Zonderman, Alan B.
; Smith, Albert V.
; Oldehinkel, Albertine J. ; De Grandi, Alessandro ; Rosenkranz, Alexander R. ; Franke, Andre ; Teren, Andrej ; Metspalu, Andres ; Hicks, Andrew A.
; Morris, Andrew P. ; Tönjes, Anke ; Morgan, Anna ; Podgornaia, Anna I. ; Peters, Annette
; Körner, Antje ; Mahajan, Anubha ; Campbell, Archie
; Freedman, Barry I. ; Spedicati, Beatrice
; Ponte, Belen ; Schöttker, Ben ; Brumpton, Ben
; Banas, Bernhard
; Krämer, Bernhard K. ; Jung, Bettina ; Åsvold, Bjørn Olav
; Smith, Blair H.
; Ning, Boting ; Penninx, Brenda W. J. H. ; Vanderwerff, Brett R. ; Psaty, Bruce M. ; Kammerer, Candace M. ; Langefeld, Carl D. ; Hayward, Caroline ; Spracklen, Cassandra N. ; Robinson-Cohen, Cassianne ; Hartman, Catharina A. ; Lindgren, Cecilia M. ; Wang, Chaolong ; Sabanayagam, Charumathi ; Heng, Chew-Kiat ; Lanzani, Chiara
; Khor, Chiea-Chuen ; Cheng, Ching-Yu
; Fuchsberger, Christian ; Gieger, Christian ; Shaffer, Christian M. ; Schulz, Christina-Alexandra ; Willer, Cristen J. ; Chasman, Daniel I. ; Gudbjartsson, Daniel F. ; Ruggiero, Daniela ; Toniolo, Daniela ; Czamara, Darina ; Porteous, David J. ; Waterworth, Dawn M. ; Mascalzoni, Deborah ; Mook-Kanamori, Dennis O. ; Reilly, Dermot F. ; Daw, E. Warwick ; Hofer, Edith ; Boerwinkle, Eric ; Salvi, Erika
; Bottinger, Erwin P. ; Tai, E-Shyong ; Catamo, Eulalia
; Rizzi, Federica
; Guo, Feng ; Rivadeneira, Fernando ; Guilianini, Franco ; Sveinbjornsson, Gardar ; Ehret, Georg ; Waeber, Gerard ; Biino, Ginevra ; Girotto, Giorgia ; Pistis, Giorgio ; Nadkarni, Girish N. ; Delgado, Graciela E. ; Montgomery, Grant W. ; Snieder, Harold ; Campbell, Harry
; White, Harvey D. ; Gao, He ; Stringham, Heather M. ; Schmidt, Helena ; Li, Hengtong ; Brenner, Hermann
; Holm, Hilma ; Kirsten, Holger ; Kramer, Holly ; Rudan, Igor
; Nolte, Ilja M. ; Tzoulaki, Ioanna ; Olafsson, Isleifur ; Martins, Jade ; Cook, James P. ; Wilson, James F.
; Halbritter, Jan
; Felix, Janine F. ; Divers, Jasmin ; Kooner, Jaspal S. ; Lee, Jeannette Jen-Mai ; O’Connell, Jeffrey ; Rotter, Jerome I. ; Liu, Jianjun ; Xu, Jie ; Thiery, Joachim ; Ärnlöv, Johan ; Kuusisto, Johanna ; Jakobsdottir, Johanna ; Tremblay, Johanne ; Chambers, John C. ; Whitfield, John B. ; Gaziano, John M. ; Marten, Jonathan ; Coresh, Josef ; Jonas, Jost B. ; Mychaleckyj, Josyf C. ; Christensen, Kaare
; Eckardt, Kai-Uwe ; Mohlke, Karen L. ; Endlich, Karlhans ; Dittrich, Katalin ; Ryan, Kathleen A. ; Rice, Kenneth M. ; Taylor, Kent D. ; Ho, Kevin ; Nikus, Kjell ; Matsuda, Koichi ; Strauch, Konstantin ; Miliku, Kozeta ; Hveem, Kristian ; Lind, Lars ; Wallentin, Lars ; Yerges-Armstrong, Laura M. ; Raffield, Laura M. ; Phillips, Lawrence S. ; Launer, Lenore J. ; Lyytikäinen, Leo-Pekka ; Lange, Leslie A. ; Citterio, Lorena ; Klaric, Lucija
; Ikram, M. Arfan ; Ising, Marcus ; Kleber, Marcus E. ; Francescatto, Margherita ; Concas, Maria Pina
; Ciullo, Marina ; Piratsu, Mario ; Orho-Melander, Marju ; Laakso, Markku ; Loeffler, Markus ; Perola, Markus ; de Borst, Martin H. ; Gögele, Martin ; Bianca, Martina La ; Lukas, Mary Ann ; Feitosa, Mary F. ; Biggs, Mary L. ; Wojczynski, Mary K. ; Kavousi, Maryam ; Kanai, Masahiro ; Akiyama, Masato
; Yasuda, Masayuki ; Nauck, Matthias ; Waldenberger, Melanie ; Chee, Miao-Li ; Chee, Miao-Ling ; Boehnke, Michael ; Preuss, Michael H. ; Stumvoll, Michael ; Province, Michael A. ; Evans, Michele K. ; O’Donoghue, Michelle L. ; Kubo, Michiaki ; Kähönen, Mika
; Kastarinen, Mika ; Nalls, Mike A. ; Kuokkanen, Mikko ; Ghanbari, Mohsen
; Bochud, Murielle ; Josyula, Navya Shilpa ; Martin, Nicholas G. ; Tan, Nicholas Y. Q. ; Palmer, Nicholette D. ; Pirastu, Nicola ; Schupf, Nicole ; Verweij, Niek
; Hutri-Kähönen, Nina ; Mononen, Nina ; Bansal, Nisha ; Devuyst, Olivier
; Melander, Olle ; Raitakari, Olli T. ; Polasek, Ozren
; Manunta, Paolo ; Gasparini, Paolo ; Mishra, Pashupati P.
; Sulem, Patrick ; Magnusson, Patrik K. E. ; Elliott, Paul ; Ridker, Paul M. ; Hamet, Pavel ; Svensson, Per O.
; Joshi, Peter K. ; Kovacs, Peter
; Pramstaller, Peter P. ; Rossing, Peter ; Vollenweider, Peter ; van der Harst, Pim
; Dorajoo, Rajkumar
; Sim, Ralene Z. H. ; Burkhardt, Ralph
; Tao, Ran ; Noordam, Raymond
; Mägi, Reedik ; Schmidt, Reinhold ; de Mutsert, Renée ; Rueedi, Rico ; van Dam, Rob M. ; Carroll, Robert J. ; Gansevoort, Ron T. ; Loos, Ruth J. F.
; Felicita, Sala Cinzia ; Sedaghat, Sanaz
; Padmanabhan, Sandosh ; Freitag-Wolf, Sandra ; Pendergrass, Sarah A. ; Graham, Sarah E. ; Gordon, Scott D. ; Hwang, Shih-Jen ; Kerr, Shona M. ; Vaccargiu, Simona ; Patil, Snehal B. ; Hallan, Stein ; Bakker, Stephan J. L. ; Lim, Su-Chi ; Lucae, Susanne ; Vogelezang, Suzanne ; Bergmann, Sven ; Corre, Tanguy ; Ahluwalia, Tarunveer S. ; Lehtimäki, Terho
; Boutin, Thibaud S.
; Meitinger, Thomas ; Wong, Tien-Yin ; Bergler, Tobias ; Rabelink, Ton J.
; Esko, Tõnu ; Haller, Toomas
; Thorsteinsdottir, Unnur ; Völker, Uwe ; Foo, Valencia Hui Xian ; Salomaa, Veikko ; Vitart, Veronique ; Giedraitis, Vilmantas ; Gudnason, Vilmundur
; Jaddoe, Vincent W. V. ; Huang, Wei ; Zhang, Weihua ; Wei, Wen Bin ; Kiess, Wieland ; März, Winfried ; Koenig, Wolfgang ; Lieb, Wolfgang ; Gao, Xin ; Sim, Xueling ; Wang, Ya Xing ; Friedlander, Yechiel ; Tham, Yih-Chung ; Kamatani, Yoichiro ; Okada, Yukinori ; Milaneschi, Yuri ; Yu, Zhi ; Thio, Chris H. L. ; van der Most, Peter J. ; de Borst, Martin H. ; Ho, Kevin ; Josyula, Navya Shilpa ; Pendergrass, Sarah A. ; Rowan, Bryce X.
; Robinson-Cohen, Cassianne ; Gaziano, John M. ; Phillips, Lawrence S. ; Tao, Ran ; Hung, Adriana M. ; Stark, Klaus J. ; Stefansson, Kari ; Böger, Carsten A. ; Hung, Adriana M. ; Kronenberg, Florian ; Köttgen, Anna ; Pattaro, Cristian ; Heid, Iris M. | Item type: | Article | ||||
|---|---|---|---|---|---|
| Open Access Type: | DEAL (Springer Gold) | ||||
| Höhe Gebühr (aus OpenAPC): | 3300.82 | ||||
| Institution der Zahlung: | Regensburg U | ||||
| Journal or Publication Title: | Communications Biology | ||||
| Publisher: | Nature | ||||
| Place of Publication: | BERLIN | ||||
| Volume: | 5 | ||||
| Page Range: | art.no.580 | ||||
| Date: | 13 June 2022 | ||||
| Institutions: | Medicine > Abteilung für Nephrologie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie | ||||
| Identification Number: |
| ||||
| Keywords: | GENOME-WIDE ASSOCIATION; ENVIRONMENT INTERACTION; QUALITY-CONTROL; METAANALYSIS; LOCI; JOINT; EFFICIENT; SMOKING; DISEASE; EXPRESSION; | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Partially | ||||
| Item ID: | 52430 |

Abstract
A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease. Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for ...

Abstract
A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease. Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n(DM) = 178,691, n(noDM) = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
Metadata last modified: 20 May 2025 06:44
Download Statistics