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Validation Study for Non-Invasive Prediction of IDH Mutation Status in Patients with Glioma Using In Vivo 1H-Magnetic Resonance Spectroscopy and Machine Learning

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Bumes, Elisabeth ; Fellner, Claudia ; Fellner, Franz A. ; Fleischanderl, Karin ; Häckl, Martina ; Lenz, Stefan ; Linker, Ralf A. ; Mirus, Tim ; Oefner, Peter J. ; Paar, Christian ; Proescholdt, Martin A. ; Riemenschneider, Markus J. ; Rosengarth, Katharina ; Weis, Serge ; Wendl, Christina ; Wimmer, Sibylle ; Hau, Peter ; Gronwald, Wolfram ; Hutterer, Markus
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Jun 2022 07:06


The isocitrate dehydrogenase (IDH) mutation status is an indispensable prerequisite for diagnosis of glioma (astrocytoma and oligodendroglioma) according to the WHO classification of brain tumors 2021 and is a potential therapeutic target. Usually, immunohistochemistry followed by sequencing of tumor tissue is performed for this purpose. In clinical routine, however, non-invasive determination of ...


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