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Validation Study for Non-Invasive Prediction of IDH Mutation Status in Patients with Glioma Using In Vivo 1H-Magnetic Resonance Spectroscopy and Machine Learning

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Bumes, Elisabeth ; Fellner, Claudia ; Fellner, Franz A. ; Fleischanderl, Karin ; Häckl, Martina ; Lenz, Stefan ; Linker, Ralf A. ; Mirus, Tim ; Oefner, Peter J. ; Paar, Christian ; Proescholdt, Martin A. ; Riemenschneider, Markus J. ; Rosengarth, Katharina ; Weis, Serge ; Wendl, Christina ; Wimmer, Sibylle ; Hau, Peter ; Gronwald, Wolfram ; Hutterer, Markus
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 22 Jun 2022 07:06


Simple Summary The enzyme isocitrate dehydrogenase (IDH) affects glioma cell metabolism in multiple ways. Mutation of IDH is not only indicative of the presence of astrocytoma or oligodendroglioma but it also comes with a better prognosis and constitutes a promising therapeutic target. Therefore, determination of IDH mutation status is essential in clinical practice. In most patients, tissue can ...


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