LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid

URN to cite this document:: urn:nbn:de:bvb:355-epub-525452
DOI to cite this document:: 10.5283/epub.52545

Decking, Sonja-Maria ; Bruss, Christina ; Babl, Nathalie ; Bittner, Sebastian ; Klobuch, Sebastian ; Thomas, Simone

; Feuerer, Markus ; Hoffmann, Petra ; Dettmer, Katja

; Oefner, Peter J.

; Renner, Kathrin

; Kreutz, Marina

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Date of publication of this fulltext: 04 Jul 2022 06:49

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Abstract

Accelerated glycolysis leads to secretion and accumulation of lactate and protons in the tumor environment and determines the efficacy of adoptive T cell and checkpoint inhibition therapy. Here, we analyzed effects of lactic acid on different human CD4 T cell subsets and aimed to increase CD4 T cell resistance towards lactic acid. In all CD4 T cell subsets analyzed, lactic acid inhibited ...