Go to content
UR Home

LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid

URN to cite this document:
DOI to cite this document:
Decking, Sonja-Maria ; Bruss, Christina ; Babl, Nathalie ; Bittner, Sebastian ; Klobuch, Sebastian ; Thomas, Simone ; Feuerer, Markus ; Hoffmann, Petra ; Dettmer, Katja ; Oefner, Peter J. ; Renner, Kathrin ; Kreutz, Marina
License: Creative Commons Attribution 4.0
PDF - Published Version
Date of publication of this fulltext: 04 Jul 2022 06:49


Accelerated glycolysis leads to secretion and accumulation of lactate and protons in the tumor environment and determines the efficacy of adoptive T cell and checkpoint inhibition therapy. Here, we analyzed effects of lactic acid on different human CD4 T cell subsets and aimed to increase CD4 T cell resistance towards lactic acid. In all CD4 T cell subsets analyzed, lactic acid inhibited ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons