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A 3D In Vivo Model for Studying Human Renal Cystic Tissue and Mouse Kidney Slices

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Bichlmayer, Eva-Marie ; Mahl, Lin ; Hesse, Leo ; Pion, Eric ; Haller, Victoria ; Moehwald, Andreas ; Hackl, Christina ; Werner, Jens M. ; Schlitt, Hans J. ; Schwarz, Siegfried ; Kainz, Philipp ; Brochhausen, Christoph ; Groeger, Christian ; Steger, Felix ; Kölbl, Oliver ; Daniel, Christoph ; Amann, Kerstin ; Kraus, Andreas ; Buchholz, Björn ; Aung, Thiha ; Haerteis, Silke
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Aug 2022 08:49


(1) Background: Autosomal dominant polycystic kidney disease (ADPKD) is a frequent monogenic disorder that leads to progressive renal cyst growth and renal failure. Strategies to inhibit cyst growth in non-human cyst models have often failed in clinical trials. There is a significant need for models that enable studies of human cyst growth and drug trials. (2) Methods: Renal tissue from ADPKD ...


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