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SAR296968, a Novel Selective Na+/Ca2+ Exchanger Inhibitor, Improves Ca2+ Handling and Contractile Function in Human Atrial Cardiomyocytes

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Hegner, Philipp ; Drzymalski, Marzena ; Biedermann, Alexander ; Memmel, Bernadette ; Durczok, Melanie ; Wester, Michael ; Floerchinger, Bernhard ; Provaznik, Zdenek ; Schmid, Christof ; Zausig, York ; Maier, Lars S. ; Wagner, Stefan
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Aug 2022 07:44


Background: In reverse-mode, cardiac sodium-calcium exchanger (NCX) can increase the cytoplasmic Ca2+ concentration in response to high intracellular Na+ levels, which may contribute to diastolic contractile dysfunction. Furthermore, increased spontaneous Ca2+ release from intracellular stores can activate forward mode NCX. The resulting transient inward current causes delayed afterdepolarization ...


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