SAR296968, a Novel Selective Na+/Ca2+ Exchanger Inhibitor, Improves Ca2+ Handling and Contractile Function in Human Atrial Cardiomyocytes

URN to cite this document:: urn:nbn:de:bvb:355-epub-527683
DOI to cite this document:: 10.5283/epub.52768

Hegner, Philipp

; Drzymalski, Marzena ; Biedermann, Alexander ; Memmel, Bernadette ; Durczok, Melanie ; Wester, Michael

; Floerchinger, Bernhard ; Provaznik, Zdenek

; Schmid, Christof ; Zausig, York ; Maier, Lars S.

; Wagner, Stefan

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 17 Aug 2022 07:44

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Abstract

Background: In reverse-mode, cardiac sodium-calcium exchanger (NCX) can increase the cytoplasmic Ca2+ concentration in response to high intracellular Na+ levels, which may contribute to diastolic contractile dysfunction. Furthermore, increased spontaneous Ca2+ release from intracellular stores can activate forward mode NCX. The resulting transient inward current causes delayed afterdepolarization ...