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Decreased GTP-stimulated adenylyl cyclase activity in
HPRT-deficient human and mouse fibroblast and rat
B103 neuroblastoma cell membranes

Pinto, Cibele S. and Seifert, Roland (2006) Decreased GTP-stimulated adenylyl cyclase activity in
HPRT-deficient human and mouse fibroblast and rat
B103 neuroblastoma cell membranes.
Journal of Neurochemistry 96 (2), pp. 454-459.

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Date of publication of this fulltext: 05 Aug 2009 13:21

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Other URL: http://www.blackwell-synergy.com/doi/abs/10.1111/j.1471-4159.2005.03570.x


Abstract

Defect of the purine salvage enzyme, hypoxanthine phosphoribosyl transferase (HPRT), results in Lesch–Nyhan disease (LND). It is unknown how the metabolic defect translates into the severe neuropsychiatric phenotype characterized by self-injurious behavior, dystonia and mental retardation. There are abnormalities in GTP, UTP and CTP concentrations in HPRT-deficient cells. Moreover, GTP, ITP, XTP, ...

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Item type:Article
Date:January 2006
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
10.1111/j.1471-4159.2005DOI
Keywords:adenylyl cyclase; B103 neuroblastoma cells; constitutive G-protein-coupled receptor activity; Gs-protein; Lesch–Nyhan disease; nucleotides
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:53
Owner only: item control page

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