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External validation of biomarkers for immune-related adverse events after immune checkpoint inhibition

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Glehr, Gunther ; Riquelme, Paloma ; Yang Zhou, Jordi ; Cordero, Laura ; Schilling, Hannah-Lou ; Kapinsky, Michael ; Schlitt, Hans J. ; Geissler, Edward K. ; Burkhardt, Ralph ; Schmidt, Barbara ; Haferkamp, Sebastian ; Hutchinson, James A. ; Kronenberg, Katharina
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 21 Oct 2022 10:37


Immune checkpoint inhibitors have revolutionized treatment of advanced melanoma, but commonly cause serious immune-mediated complications. The clinical ambition of reserving more aggressive therapies for patients least likely to experience immune-related adverse events (irAE) has driven an extensive search for predictive biomarkers. Here, we externally validate the performance of 59 previously ...


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